1,1,1-Trifluoro-2-isothiocyanatoethane → HCID 178485065, 화합물

HRID 34757

반응식

HRID 34757 반응식
[F:1][C:2]([F:8])([F:7])[CH2:3][N:4]=[C:5]=[S:6].[NH2:9][C:10]1[S:11][CH:12]=[C:13]([CH2:15][S:16][CH2:17][CH2:18][NH:19][C:20]([NH:24][CH3:25])=[N:21][C:22]#[N:23])[N:14]=1>CN(C)C=O>[F:1][C:2]([F:8])([F:7])[CH2:3][NH:4][C:5](=[S:6])[NH:9][C:10]1[S:11][CH:12]=[C:13]([CH2:15][S:16][CH2:17][CH2:18][NH:19][C:20]([NH:24][CH3:25])=[N:21][C:22]#[N:23])[N:14]=1

참가 물질

4

반응물 2

HCID 138837771,1,1-Trifluoro-2-isothiocyanatoethaneHCID 178485066HCID 178485066, 화합물

생성물 1

HCID 178485065HCID 178485065, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of 2,2,2-trifluoroethyl isothiocyanate (0.68 g.) and 2-amino-4-[2-(2-cyano-3-methylguanidino)ethylthiomethyl]thiazole (1.08 g.) in dimethylformamide (5 ml.) was maintained at 60° for 4 hours and then evaporated to dryness. The residue was recrystallised from acetonitrile to give 2-[3-(2,2,2-trifluoroethyl)thioureido]-4-[2-(2-cyano-3-methylguanidino)ethylthiomethyl]thiazole, m.p. 157°-158°.

후처리

  1. temperaturewas maintained at 60° for 4 hours
  2. customevaporated to dryness
  3. customThe residue was recrystallised from acetonitrile

출처 및 근거

ORD 기록
ord-5372c98e3cfb479abc30ca7e91934a83
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04762932

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