Iodoethane → 2H-1,5-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-1-ethyl-

반응식

[O:1]=[C:2]1[NH:8][C:7]2[CH:9]=[CH:10][CH:11]=[CH:12][C:6]=2[NH:5][CH2:4][CH2:3]1.[CH2:13](I)[CH3:14]>>[CH2:13]([N:8]1[C:7]2[CH:9]=[CH:10][CH:11]=[CH:12][C:6]=2[NH:5][CH2:4][CH2:3][C:2]1=[O:1])[CH3:14]

참가 물질

반응물 2

HCID 6340Iodoethane

HCID 2237712,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one

생성물 1

HCID 30782002H-1,5-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-1-ethyl-

실험 절차

2-Oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine (1.95 g, 11.96 mmol) was reacted with ethyl iodide (1.4 ml, 17.5 mmol) according to the procedure in Example 18A. The product was purified by flash chromatography on silica (eluant EtOAc); yield 1.70 g (75%).

후처리

customThe product was purified by flash chromatography on silica (eluant EtOAc)

출처 및 근거

ORD 기록: ord-c59cc29e10ad497786d80d9cece45616
출처 데이터셋: uspto-grants-2007_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07176195B2

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