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Sodium Hydroxide → 2-(3,5-Bis-trifluoromethyl-phenyl)-N-(6'-chloro-2-methyl-[3,4]bipyridinyl-3'-yl)-N-methyl-isobutyramide

HRID 347684
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반응식

HRID 347684 반응식
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([NH:8][CH3:9])=[C:4]([C:10]2[C:11]([CH3:16])=[N:12][CH:13]=[CH:14][CH:15]=2)[CH:3]=1.C([Li])CCC.[F:22][C:23]([F:41])([F:40])[C:24]1[CH:25]=[C:26]([C:34]([CH3:39])([CH3:38])[C:35](Cl)=[O:36])[CH:27]=[C:28]([C:30]([F:33])([F:32])[F:31])[CH:29]=1.[OH-].[Na+]>C1COCC1>[F:33][C:30]([F:31])([F:32])[C:28]1[CH:27]=[C:26]([C:34]([CH3:38])([CH3:39])[C:35]([N:8]([C:5]2[CH:6]=[N:7][C:2]([Cl:1])=[CH:3][C:4]=2[C:10]2[C:11]([CH3:16])=[N:12][CH:13]=[CH:14][CH:15]=2)[CH3:9])=[O:36])[CH:25]=[C:24]([C:23]([F:40])([F:22])[F:41])[CH:29]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 14798Sodium HydroxideHCID 112671412-(3,5-Bis(trifluoromethyl)phenyl)-2-methylpropanoyl chlorideHCID 586946066'-Chloro-N,2-dimethyl-[3,4'-bipyridin]-3'-amineHCID 178418339Butyllithium

생성물 1

HCID 210836352-(3,5-Bis-trifluoromethyl-phenyl)-N-(6'-chloro-2-methyl-[3,4]bipyridinyl-3'-yl)-N-methyl-isobutyramide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of (6′-chloro-2-methyl-[3,4′]bipyridinyl-3′-yl)-methyl-amine in THF is added a solution of n-butyllithium in hexanes at about −78° C. After 15 min 2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl chloride is added. The reaction mixture is allowed to warm to room temperature during 30 min. After addition of an aqueous sodium hydroxide solution, the mixture is extracted with dichloromethane, dried and concentrated to give the compound 2-(3,5-Bis-trifluoromethyl-phenyl)-N-(6′-chloro-2-methyl-[3,4′]bipyridinyl-3′-yl)-N-methyl-isobutyramide of formula II-2.

후처리

  1. extractionthe mixture is extracted with dichloromethane
  2. customdried
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-ea8fb2a6a11d4830890dea7a9e4484f6
출처 데이터셋
uspto-grants-2007_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07176205B2

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