Benzylamine → 2-Amino-3-cyano-4-benzylaminoquinoline

HRID 347764노트

반응식

HRID 347764 반응식
[NH2:1][C:2]1[C:11]([C:12]#[N:13])=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH2:15]([NH2:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>O>[NH2:1][C:2]1[C:11]([C:12]#[N:13])=[C:10]([NH:22][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

참가 물질

4

반응물 2

HCID 7504BenzylamineHCID 114811212-Amino-3-cyano4-chloroquinoline

생성물 1

HCID 112888282-Amino-3-cyano-4-benzylaminoquinoline

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
130 °C

실험 절차

5 g of 2-amino-3-cyano-4-chloroquinolin and 11 ml of benzylamine are heated under stirring at 130° C. The reaction mixture is poured onto 50 ml of water, the resulting precipitate is filtered off, washed with 50 ml of water. The pale-yellow precipitate is recrystallized from dimethylformamide to obtain 5.2 g of the title compound. Mp.: 206° C.

후처리

  1. filtrationthe resulting precipitate is filtered off
  2. washwashed with 50 ml of water
  3. customThe pale-yellow precipitate is recrystallized from dimethylformamide

출처 및 근거

ORD 기록
ord-8d86c108204f41c5bc875ed3fd3db3e5
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07176213B2

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