Methanol → Methyl (2-chlorophenyl)acetate

HRID 347780

반응식

HRID 347780 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([OH:11])=[O:10].[CH3:12]O>S(=O)(=O)(O)O>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([O:11][CH3:12])=[O:10]

참가 물질

4

반응물 2

HCID 887MethanolHCID 17124o-Chlorophenylacetic acid

생성물 1

HCID 93683Methyl (2-chlorophenyl)acetate수율 97.5%

시약·촉매·용매 1

HCID 1118Sulfuric Acid촉매

실험 절차

To 2-chlorophenylacetic acid (1.04 g, 6 mmol) in MeOH (25 mL) was added sulfuric acid (6 drops) and the solution was refluxed for 16 hours. After concentration, the residue was taken up in ethyl acetate and washed with sat'd aq. NaHCO3, H2O and brine. The organic layer was dried over Na2SO4 and concentrated to give methyl (2-chlorophenyl)acetate 6a (1.08 g, 97.5% ) as a yellowish oil. GCMS (EI) m/z 184, 186 (M+).

후처리

  1. temperaturethe solution was refluxed for 16 hours
  2. concentrationAfter concentration
  3. washwashed with sat'd aq. NaHCO3, H2O and brine
  4. dry with materialThe organic layer was dried over Na2SO4
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-3743fead2e244e8f877581d62ad96443
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07176211B2

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