Ammonia → Oxane-4-carboxamide

HRID 347859

반응식

HRID 347859 반응식
[O:1]1[CH2:6][CH2:5][CH:4]([C:7]([O:9]C)=O)[CH2:3][CH2:2]1.[NH3:11]>>[O:1]1[CH2:6][CH2:5][CH:4]([C:7]([NH2:11])=[O:9])[CH2:3][CH2:2]1

참가 물질

3

반응물 2

HCID 222AmmoniaHCID 27735202H-Pyran-4-carboxylic acid, tetrahydro-, methyl ester

생성물 1

HCID 13197203Oxane-4-carboxamide수율 74.6%

실험 절차

Concentrated aqueous ammonia (50 mL) was added to methyl tetrahydro-2H-pyran-4-carboxylate (50 g, 347 mmol) and the reaction mixture was stirred for 43.5 hours at room temperature. The reaction mixture was then cooled in an ice water bath, after which the precipitate was filtered out and dried under reduced pressure at 40° C. to afford 33.4 g of the title compound (74.6% yield).

후처리

  1. temperatureThe reaction mixture was then cooled in an ice water bath
  2. filtrationafter which the precipitate was filtered out
  3. customdried under reduced pressure at 40° C.

출처 및 근거

ORD 기록
ord-252e002dbf1d499fbd2f04606d198237
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07176216B2

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