반응식
[CH3:1][O:2][C:3]([CH:5]1[C:9](=O)[CH2:8][S:7][CH2:6]1)=[O:4].[C-:11]#[N:12].[K+].C(O)(=O)C.OP(O)(O)=O>CO.O.[Cl-].[Na+].O>[CH3:1][O:2][C:3]([CH:5]1[CH:9]([C:11]#[N:12])[CH2:8][S:7][CH2:6]1)=[O:4]참가 물질
8
반응물 4
생성물 1
시약·촉매·용매 3
반응 조건
- 온도
- 0 °C
실험 절차
To a solution of 4-oxotetrahydro thiophene-3-carboxylic acid methyl ester (4 g, 25 mmol) in methanol (7 ml), cooled at 0° C., a solution of potassium cyanide (1.68 g, 30 mmol) in water (10 ml) was added. The mixture was acidified with acetic acid (1.5 ml, 25 mmol) and stirred at 0° C. for 8 hours. Then the mixture was acidified with H3PO4 and diluted with brine (50 ml) and extracted with CH2Cl2 (4×30 ml). The organic layers were dried over sodium sulfate and concentrated to give 4-cyano-tetrahydro thiophene-3-carboxylic acid methyl ester in 75% yield.
후처리
- extractionextracted with CH2Cl2 (4×30 ml)
- dry with materialThe organic layers were dried over sodium sulfate
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-d3cf14a7469c4dbfa5115cc78f7159d4
- 출처 데이터셋
- uspto-grants-2007_02
- 특허 번호
- US07176241B2
연결된 노트
불러오는 중…