2-Fluorophenol → Ethyl 2-(2-fluorophenoxy)propanoate
반응식
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[OH:8].C([O-])([O-])=O.[Cs+].[Cs+].Br[CH:16]([CH3:22])[C:17]([O:19][CH2:20][CH3:21])=[O:18]>CN(C=O)C>[CH2:20]([O:19][C:17](=[O:18])[CH:16]([O:8][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[F:1])[CH3:22])[CH3:21]참가 물질
5
반응 조건
- 온도
- 90 °C
실험 절차
2-Fluorophenol (0.30 mol), Cs2CO3 (197.0 g, 0.61 mol), and ethyl 2-bromopropionate (54.3 g, 0.30 mol) were combined in anhydrous DMF (1000 mL) and stirred at 90° C. under an atmosphere of nitrogen. After 16 h, the DMF was removed in vacuo. The residue was dissolved in ethyl acetate (300 mL) and washed twice with water and once with brine. The organic layer was dried over Na2SO4 and concentrated in vacuo to produce an oil.
후처리
- customthe DMF was removed in vacuo
- dissolutionThe residue was dissolved in ethyl acetate (300 mL)
- washwashed twice with water and once with brine
- dry with materialThe organic layer was dried over Na2SO4
- concentrationconcentrated in vacuo
- customto produce an oil
출처 및 근거
- ORD 기록
- ord-95e3049befcd40758a43eced547af7f9
- 출처 데이터셋
- uspto-grants-2007_02
- 특허 번호
- US07176224B2
반응 노트
불러오는 중…