Magnesium Chloride → HCID 178488147, 화합물

HRID 348429

반응식

HRID 348429 반응식
[K].[CH3:2][O:3][C:4]1[CH:25]=[CH:24][C:7]2[NH:8][C:9]([S@:11]([CH2:13][C:14]3[C:19]([CH3:20])=[C:18]([O:21][CH3:22])[C:17]([CH3:23])=[CH:16][N:15]=3)=[O:12])=[N:10][C:6]=2[CH:5]=1.[Cl-].[Mg+2].[Cl-]>O>[CH3:23][C:17]1[CH:16]=[N:15][C:14]([CH2:13][S+:11]([O-:12])[C:9]2[NH:8][C:7]3[CH:24]=[CH:25][C:4]([O:3][CH3:2])=[CH:5][C:6]=3[N:10]=2)=[C:19]([CH3:20])[C:18]=1[O:21][CH3:22]

참가 물질

5

반응물 3

HCID 5360315Magnesium ChlorideHCID 5462222PotassiumHCID 9568614Esomeprazole

생성물 1

HCID 178488147HCID 178488147, 화합물수율 76.9%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
25 °C

실험 절차

Potassium salt of (S)-5-Methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl) methylsulfinyl]1-H-benzimidazole (Esomeprazole potassium) (5.2 gm) was dissolved in water (75 ml). To this solution, was added magnesium chloride solution (1.4 gm in 50 ml water), and then the contents were stirred for 1 hour at 25° C. The solid precipitated was filtered, washed with water and dried under vacuum for 12 hours at 40° C. to obtain 4.0 gm of esomeprazole magnessium dihydrate (enantiomeric excess: 99.7%).

후처리

  1. customThe solid precipitated
  2. filtrationwas filtered
  3. washwashed with water
  4. customdried under vacuum for 12 hours at 40° C.

출처 및 근거

ORD 기록
ord-7e116e956ae54210a4e262617ce47c1d
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07176319B2

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