2-Phthalimidomethyl-6-(4-dipropylaminobutyl)naphthalene → 2-Aminomethyl-6-(4-dipropylaminobutyl)naphthalene

HRID 348750

반응식

HRID 348750 반응식
C1(=O)[N:5]([CH2:6][C:7]2[CH:16]=[CH:15][C:14]3[C:9](=[CH:10][CH:11]=[C:12]([CH2:17][CH2:18][CH2:19][CH2:20][N:21]([CH2:25][CH2:26][CH3:27])[CH2:22][CH2:23][CH3:24])[CH:13]=3)[CH:8]=2)C(=O)C2=CC=CC=C12>CN.CO>[NH2:5][CH2:6][C:7]1[CH:16]=[CH:15][C:14]2[C:9](=[CH:10][CH:11]=[C:12]([CH2:17][CH2:18][CH2:19][CH2:20][N:21]([CH2:25][CH2:26][CH3:27])[CH2:22][CH2:23][CH3:24])[CH:13]=2)[CH:8]=1

참가 물질

3

반응물 1

HCID 210843922-Phthalimidomethyl-6-(4-dipropylaminobutyl)naphthalene

생성물 1

HCID 210843902-Aminomethyl-6-(4-dipropylaminobutyl)naphthalene수율 127.5%

시약·촉매·용매 1

HCID 57454252Monomethylamine methanol용매

실험 절차

The compound (75.0 mg) obtained in Example 124-3 was dissolved in a 40% methylamine/methanol solution (2.0 ml) and stirred overnight at room temperature. After completion of the reaction, the solvent was distilled off and then the residue was added with a 1 mol/l sodium hydroxide aqueous solution and stirred. The solution was subjected to extraction with chloroform and the extract was then washed with saturated saline solution. Subsequently, the organic layer was dried with anhydrous sodium sulfate and the solvent was then distilled off, thereby obtaining the subject compound (67.5 mg) as a colorless oily substance.

후처리

  1. customAfter completion of the reaction
  2. distillationthe solvent was distilled off
  3. additionthe residue was added with a 1 mol/l sodium hydroxide aqueous solution
  4. stirringstirred
  5. extractionThe solution was subjected to extraction with chloroform
  6. washthe extract was then washed with saturated saline solution
  7. dry with materialSubsequently, the organic layer was dried with anhydrous sodium sulfate
  8. distillationthe solvent was then distilled off

출처 및 근거

ORD 기록
ord-06f285c9b51643fe93d59be419362a9b
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07176227B2

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