Methanol → 3-[5-(3-Methoxy-3-oxopropyl)-1,3-oxazol-2-yl]benzoic acid

HRID 348883

반응식

HRID 348883 반응식
[C:1]([CH2:4][CH2:5][C:6]1[O:10][C:9]([C:11]2[CH:12]=[C:13]([CH:17]=[CH:18][CH:19]=2)[C:14]([OH:16])=[O:15])=[N:8][CH:7]=1)([OH:3])=[O:2].S(Cl)(Cl)=O.[CH3:24]O>>[CH3:24][O:2][C:1](=[O:3])[CH2:4][CH2:5][C:6]1[O:10][C:9]([C:11]2[CH:12]=[C:13]([CH:17]=[CH:18][CH:19]=2)[C:14]([OH:16])=[O:15])=[N:8][CH:7]=1

참가 물질

4

반응물 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 210856903-[5-(2-Carboxyethyl)-1,3-oxazol-2-yl]benzoic acid

생성물 1

HCID 210856913-[5-(3-Methoxy-3-oxopropyl)-1,3-oxazol-2-yl]benzoic acid

실험 절차

To 3-[5-(2-carboxyethyl)-1,3-oxazol-2-yl]benzoic acid (317 mg, 1.2 mmol) in methanol (5 mL) is added thionyl chloride (4.4 μL, 0.06 mmol), and the reaction is stirred at room temperature 16 h. The solution is concentrated under reduced pressure to give the title compound. ESI MS m/z 274.1 [M−H]−.

후처리

  1. concentrationThe solution is concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-c873f96b4449495daa857fc40856a66d
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07176242B2

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