Water → 3-{[(2-Methoxyethyl)(methyl)amino]methyl}-5-methylbenzoic Acid

HRID 348918

반응식

HRID 348918 반응식
[CH3:1][O:2][CH2:3][CH2:4][N:5]([CH2:7][C:8]1[CH:9]=[C:10]([CH:15]=[C:16]([CH3:18])[CH:17]=1)[C:11]([O:13]C)=[O:12])[CH3:6].O.[OH-].[Li+]>CO.O1CCCC1>[CH3:1][O:2][CH2:3][CH2:4][N:5]([CH2:7][C:8]1[CH:9]=[C:10]([CH:15]=[C:16]([CH3:18])[CH:17]=1)[C:11]([OH:13])=[O:12])[CH3:6]

참가 물질

6

반응물 3

HCID 962WaterHCID 3939Lithium HydroxideHCID 21086148Methyl 3-{[(2-methoxyethyl)(methyl)amino]methyl}-5-methylbenzoate

생성물 1

HCID 210856713-{[(2-Methoxyethyl)(methyl)amino]methyl}-5-methylbenzoic Acid

시약·촉매·용매 2

HCID 887Methanol용매HCID 8028Tetrahydrofuran용매

실험 절차

To a stirred solution of methyl 3-{[(2-methoxyethyl)(methyl)amino]methyl}-5-methylbenzoate (180 mg, 0.72 mmol) in methanol (2 mL), tetrahydrofuran (1 mL), and water (1 mL) is added lithium hydroxide (302 mg, 7.2 mmol) and the reaction mixture stirred at room temperature for 2 h. The reaction mixture is concentrated under reduced pressure, dissolved in methylene chloride, filtered, and the filtrate concentrated under reduced pressure to provide the title compound. ESI MS m/z 238 [M+H]+.

후처리

  1. concentrationThe reaction mixture is concentrated under reduced pressure
  2. dissolutiondissolved in methylene chloride
  3. filtrationfiltered
  4. concentrationthe filtrate concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-28737269f39c4988859041fb350161a7
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07176242B2

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