Ethanol → Ethanol water glycerin glycerol monooleate

HRID 349141

반응식

HRID 349141 반응식
[CH2:1]([OH:3])[CH3:2].[C:4]([O:23][CH2:24][CH:25]([CH2:27][OH:28])[OH:26])(=[O:22])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11]/[CH:12]=[CH:13]\[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21]>O.OCC(CO)O>[CH2:1]([OH:3])[CH3:2].[OH2:22].[OH:23][CH2:24][CH:25]([CH2:27][OH:28])[OH:26].[C:4]([O:23][CH2:24][CH:25]([CH2:27][OH:28])[OH:26])(=[O:22])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11]/[CH:12]=[CH:13]\[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21]

참가 물질

5

반응물 2

HCID 702EthanolHCID 5283468Glyceryl Monooleate

생성물 1

HCID 131716747Ethanol water glycerin glycerol monooleate

시약·촉매·용매 2

HCID 753Glycerol용매HCID 962Water용매

실험 절차

95% ethanol (USP) was diluted with water (USP), glycerin (USP), and glycerol monooleate (Eastman Chemical, Kingsport N.Y.) to provide a final solution at ethanol/water/glycerin/glycerol monooleate percent ratios of 35/59/5/1, respectively. Oxybutynin free base was then dissolved into the above solution to a concentration of 10 mg/gram. The resultant solution was then gelled with 1% hydroxypropyl cellulose (Aqualon, Wilmington, Del.) to provide a final oxybutynin gel. One to two grams of the above gel is applied topically to approximately 200 cm2 surface area on the chest, torso, and or arms to provide topical administration of oxybutynin.

출처 및 근거

ORD 기록
ord-90ae7c7719814c368898fc3f10e3b49c
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07179483B2

연결된 노트

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