P-Chloroacetophenone → (1S)-1-(4-chlorophenyl)ethan-1-ol

Washed phaseolus aureus L (green grams) 50 g. were taken into a conical flask and allowed to soak in deionised water (400 ml) for a period of 24 hr. 4-chloroacetophenone (0.500 g; 0.0032 moles) I(b) was added to the soaked phaseolus aureus L (green grams) in the above water, covered and allowed to shake for 24 hr at 15–20° C. Then the green grams were filtered off and washed with deionised water (3×100 ml). The combined filtrate was extracted with chloroform (3×500 ml). The chloroform layer was dried and the crude product obtained (340 mg). Pure 1-(4-chlorophenyl-(1S)-ethan-1-ol II(b) was obtained after column chromatography with silica gel using chloroform as eluent.

1. washWashed phaseolus aureus L (green grams) 50 g
2. customwere taken into a conical flask
3. waitto shake for 24 hr at 15–20° C
4. filtrationThen the green grams were filtered off
5. washwashed with deionised water (3×100 ml)
6. extractionThe combined filtrate was extracted with chloroform (3×500 ml)
7. dry with materialThe chloroform layer was dried
8. customthe crude product obtained (340 mg)

ORD 기록

ord-dd6cbdb892504684acf7ea8a75fa791e

출처 데이터셋

uspto-grants-2007_02

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US07179624B2