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Phthalimide → HCID 69412703, 화합물

HRID 349163
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HRID 349163 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]([CH2:13][O:14][C:15]3[CH:16]=[C:17]([CH2:21]O)[CH:18]=[CH:19][CH:20]=3)[S:11][CH:12]=2)=[CH:4][CH:3]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[C:42]1(=[O:52])[NH:46][C:45](=[O:47])[C:44]2=[CH:48][CH:49]=[CH:50][CH:51]=[C:43]12.CCOC(/N=N/C(OCC)=O)=O>O1CCCC1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:9]=[C:10]([CH2:13][O:14][C:15]3[CH:16]=[C:17]([CH2:21][N:46]4[C:45](=[O:47])[C:44]5=[CH:48][CH:49]=[CH:50][CH:51]=[C:43]5[C:42]4=[O:52])[CH:18]=[CH:19][CH:20]=3)[S:11][CH:12]=2)=[CH:6][CH:7]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 6809PhthalimideHCID 11776TriphenylphosphineHCID 5462977Diethyl azodicarboxylateHCID 69413563HCID 69413563, 화합물2회

생성물 1

HCID 69412703HCID 69412703, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

The phenylmethylalcohol compound (1.98 grams) (Scheme C, Compound C1) was dissolved in tetrahydrofuran (100 mL). Triphenylphosphine (1.84 grams), phthalimide (1.03 grams) and diethylazodicarboxylate (1.10 mL) were added to the mixture which was then stirred for 16 hours before being evaporated in vacuo. The residue was column chromatographed (silica gel) using a mobile phase of hexane-ethyl acetate 2:1 to give a N-[3-[[4-(4-chlorophenyl)-2-thiazolyl]methoxy]phenylmethyl]phthalimide (Scheme C, Compound C2). Mp 156.5–157.5° C.; MS 461 (MH+).

후처리

  1. custombefore being evaporated in vacuo
  2. customchromatographed (silica gel)

출처 및 근거

ORD 기록
ord-6cad1b2aa9b34e7da1cceb21a86b45c4
출처 데이터셋
uspto-grants-2007_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07179808B2

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