Triethylamine → 2,2,2-Triphenylacetohydrazide

HRID 349169노트

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HRID 349169 반응식
[C:1]1([C:7]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:8](O)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.F[P-](F)(F)(F)(F)F.FC(N(C)C)=[N+](C)C.C(N(CC)CC)C.O.[NH2:46][NH2:47]>CN(C)C=O.O>[C:1]1([C:7]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:8]([NH:46][NH2:47])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

7

반응물 4

HCID 8471TriethylamineHCID 24654Hydrazine hydrate (1:1)HCID 68992Triphenylacetic acidHCID 2774761Tetramethylfluoroformamidinium hexafluorophosphate

생성물 1

HCID 153699862,2,2-Triphenylacetohydrazide수율 65%

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

반응 조건

온도
0 °C

실험 절차

Triphenylacetic acid (499.6 mg, 1.73 mmol) was dissolved in N,N-dimethylformamide (DMF, 3.46 mL). Fluoro-N,N,N′,N′-tetramethylformamidinium hexafluorophosphate (TFFH, 460.1 mg, 1.742 mmol) and anhydrous triethylamine (480 μl, 3.44 mmol) were added and the solution was cooled to 0° C. After 10 minutes hydrazine monohydrate (168 μl, 3.46 mmol) was added. The reaction was allowed to warm, and after stirring at room temperature for 30 minutes, it was worked up by adding water and filtering the resulting precipitate. The precipitate was dried under vacuum to give 2,2,2-triphenylacetohydrazide (340.1 mg).

후처리

  1. temperatureto warm
  2. filtrationfiltering the resulting precipitate
  3. customThe precipitate was dried under vacuum

출처 및 근거

ORD 기록
ord-0e9c49cf87154fe1b840c06a4595de6a
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07179802B2

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