Hydrochloric Acid → N-(2-aminoethyl)-3-phenoxypyridine-2-carboxamide hydrochloride

HRID 34938노트

반응식

HRID 34938 반응식
[O:1]([C:8]1[C:9]([C:14]([NH:16][CH2:17][CH2:18][NH:19]C(=O)OC(C)(C)C)=[O:15])=[N:10][CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.FC(F)(F)C(O)=O.[ClH:34]>>[ClH:34].[NH2:19][CH2:18][CH2:17][NH:16][C:14]([C:9]1[C:8]([O:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[CH:13][CH:12]=[CH:11][N:10]=1)=[O:15]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 6422Trifluoroacetic acidHCID 13800228t-Butyl [2-(3-phenoxypyridine-2-carboxamido)ethyl]carbamate

생성물 1

HCID 13800260N-(2-aminoethyl)-3-phenoxypyridine-2-carboxamide hydrochloride

실험 절차

8.7 g of t-butyl [2-(3-phenoxypyridine-2-carboxamido)ethyl]carbamate were reacted with trifluoroacetic acid in an analogous manner to that described in Example 3, paragraph 2. The residue was converted into the hydrochloride which was recrystallized twice from ethanol/ether, whereby there was obtained N-(2-aminoethyl)-3-phenoxypyridine-2-carboxamide hydrochloride as white crystals, m.p. 180°-186°.

후처리

  1. customwas recrystallized twice from ethanol/ether

출처 및 근거

ORD 기록
ord-64f995007abf4ea6972aba508349a44e
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04764522

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