Chloroform → Methyl 3-acetamido-4,5-dichlorothiophene-2-carboxylate

HRID 349428노트

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HRID 349428 반응식
[C:1]([NH:4][C:5]1[CH:9]=C[S:7][C:6]=1[C:10]([O:12][CH3:13])=[O:11])(=[O:3])[CH3:2].S(Cl)([Cl:17])(=O)=O.[CH:19]([Cl:22])(Cl)Cl>>[C:1]([NH:4][C:5]1[C:9]([Cl:17])=[C:19]([Cl:22])[S:7][C:6]=1[C:10]([O:12][CH3:13])=[O:11])(=[O:3])[CH3:2]

참가 물질

4

반응물 3

HCID 6212Chloroform2회HCID 24648Sulfuryl chlorideHCID 729216methyl 3-acetamidothiophene-2-carboxylate

생성물 1

HCID 22139803Methyl 3-acetamido-4,5-dichlorothiophene-2-carboxylate

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온도
40 °C

실험 절차

was obtained by reacting 19.9 g of methyl 3-acetylaminothiophene-2-carboxylate in 100 ml of chloroform with 17.9 ml of sulfuryl chloride (SO2Cl2) in 120 ml of chloroform by stirring at 40° C. for 2 hours and subsequently boiling under reflux conditions for 15 minutes. After the solvent had been distilled off, the residue was crystallized in ethyl acetate.

후처리

  1. customwas obtained
  2. waitsubsequently boiling under reflux conditions for 15 minutes
  3. distillationAfter the solvent had been distilled off
  4. customthe residue was crystallized in ethyl acetate

출처 및 근거

ORD 기록
ord-1be62623a17a47cabd5b61e31375bf48
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07179830B2

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