HCID 22139808, 화합물 → methyl 3-amino-4-chlorothiophene-2-carboxylate
반응식
C([NH:4][C:5]1[C:9]([Cl:10])=[CH:8][S:7][C:6]=1[C:11]([O:13][CH3:14])=[O:12])(=O)C>CO.Cl>[NH2:4][C:5]1[C:9]([Cl:10])=[CH:8][S:7][C:6]=1[C:11]([O:13][CH3:14])=[O:12]참가 물질
4
실험 절차
was obtained by stirring a solution of 7 g of methyl 3-acetylamino-4-chlorothiophene-2-carboxylate in a mixture of 50 ml of methanol and 50 ml of concentrated hydrochloric acid at 60° C. for 4 hours and at room temperature for 2 days. The mixture was filtered, the solvent was distilled to about ⅓ of the starting volume, approx. 100 ml of water were added and the crystals were filtered off after stirring at room temperature. Crystalline product. M.p. 62–64° C.
후처리
- customwas obtained
- filtrationThe mixture was filtered
- distillationthe solvent was distilled to about ⅓ of the starting volume, approx. 100 ml of water
- additionwere added
- filtrationthe crystals were filtered off
출처 및 근거
- ORD 기록
- ord-7f266a2370f04a3e9cd7fc83367554db
- 출처 데이터셋
- uspto-grants-2007_02
- 특허 번호
- US07179830B2
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