Hydrochloric Acid → 5-bromo-N-(2-aminoethyl)-2-thiophenecarboxamide hydrochloride

HRID 34947노트

반응식

HRID 34947 반응식
[NH:1]([CH2:5][CH2:6][NH:7][C:8]([C:10]1[S:11][C:12]([Br:15])=[CH:13][CH:14]=1)=[O:9])C(C)=O.[ClH:16]>>[ClH:16].[Br:15][C:12]1[S:11][C:10]([C:8]([NH:7][CH2:6][CH2:5][NH2:1])=[O:9])=[CH:14][CH:13]=1

참가 물질

3

반응물 2

HCID 313Hydrochloric AcidHCID 2604169N-(2-acetamidoethyl)-5-bromothiophene-2-carboxamide

생성물 1

HCID 138002765-bromo-N-(2-aminoethyl)-2-thiophenecarboxamide hydrochloride

실험 절차

N-(2-Acetaminoethyl)-5-bromo-2-thiophenecarboxamide was reacted with hydrochloric acid in an analogous manner to that described in Example 1, paragraph 3. The residue was dissolved in alcohol (pH 1), filtered and concentrated to about 300 ml under reduced pressure. After cooling to 5° the product was filtered off under suction and dried, whereby 5-bromo-N-(2-aminoethyl)-2-thiophenecarboxamide hydrochloride was obtained as white crystals, m.p. 221°-222°, after recrystallization from ethanol.

후처리

  1. filtrationfiltered
  2. concentrationconcentrated to about 300 ml under reduced pressure
  3. temperatureAfter cooling to 5° the product
  4. filtrationwas filtered off under suction
  5. customdried

출처 및 근거

ORD 기록
ord-54ae05bc05c541b0a898ca7dc86540e6
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04764522

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