Picolinic acid → Pyridine-2-carbonyl chloride

HRID 34949

반응식

HRID 34949 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]([OH:9])=O.S(Cl)([Cl:12])=O>C1(C)C=CC=CC=1.CN(C)C=O>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]([Cl:12])=[O:9]

참가 물질

5

반응물 2

HCID 1018Picolinic acidHCID 24386Thionyl Chloride

생성물 1

HCID 135034Pyridine-2-carbonyl chloride

시약·촉매·용매 2

HCID 6228Dimethylformamide촉매HCID 1140Toluene용매

실험 절차

10.0% of pyridine-2-carboxylic acid were suspended in 150 ml of toluene and the suspension was heated to reflux for 2 hours with 17.7 ml of thionyl chloride and 3 drops of dimethylformamide. Thereafter, the mixture was evaporated to dryness under reduced pressure, the residue was treated with toluene and again evaporated to dryness. There was obtained picolinic acid chloride as dark green crystals which were used directly in the next step.

후처리

  1. temperaturethe suspension was heated
  2. customThereafter, the mixture was evaporated to dryness under reduced pressure
  3. additionthe residue was treated with toluene
  4. customagain evaporated to dryness

출처 및 근거

ORD 기록
ord-0c9b8f17431e45df938f2c9f0e1931bb
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04764522

연결된 노트

불러오는 중…