Picolinic acid → Pyridine-2-carbonyl chloride
반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]([OH:9])=O.S(Cl)([Cl:12])=O>C1(C)C=CC=CC=1.CN(C)C=O>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]([Cl:12])=[O:9]참가 물질
5
실험 절차
10.0% of pyridine-2-carboxylic acid were suspended in 150 ml of toluene and the suspension was heated to reflux for 2 hours with 17.7 ml of thionyl chloride and 3 drops of dimethylformamide. Thereafter, the mixture was evaporated to dryness under reduced pressure, the residue was treated with toluene and again evaporated to dryness. There was obtained picolinic acid chloride as dark green crystals which were used directly in the next step.
후처리
- temperaturethe suspension was heated
- customThereafter, the mixture was evaporated to dryness under reduced pressure
- additionthe residue was treated with toluene
- customagain evaporated to dryness
출처 및 근거
- ORD 기록
- ord-0c9b8f17431e45df938f2c9f0e1931bb
- 출처 데이터셋
- uspto-grants-1988_08
- 특허 번호
- US04764522
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