Hydrochloric Acid → 3-(5-Amino-1-methylpyrazol-4-yl)propylamine dihydrochloride
반응식
[NH2:1][C:2]1[N:6]([CH3:7])[N:5]=[CH:4][C:3]=1[CH2:8][CH2:9][CH2:10][N:11]1C(=O)C2=CC=CC=C2C1=O.[ClH:22]>O>[ClH:22].[ClH:22].[NH2:1][C:2]1[N:6]([CH3:7])[N:5]=[CH:4][C:3]=1[CH2:8][CH2:9][CH2:10][NH2:11]참가 물질
4
실험 절차
5-Amino-1-methyl-4-(3-phthalimidopropyl)pyrazole (1.42 g, 5 mmol) was added to concentrated hydrochloric acid (10 ml) at room temperature, and the mixture was stirred under reflux for 23 hours. To the reaction mixture was added water (50 ml), and most of insoluble materials were removed by filtration. The filtrate was washed with ethyl acetate, and the aqueous layer was concentrated in vacuo. The residue was triturated with 2-propanol and dried in vacuo to give 3-(5-amino-1-methylpyrazol-4-yl)propylamine dihydrochloride (700 mg) as a solid.
후처리
- temperatureunder reflux for 23 hours
- custommost of insoluble materials were removed by filtration
- washThe filtrate was washed with ethyl acetate
- concentrationthe aqueous layer was concentrated in vacuo
- customThe residue was triturated with 2-propanol
- customdried in vacuo
출처 및 근거
- ORD 기록
- ord-106e3c25fe28488ab8f6102497abc411
- 출처 데이터셋
- uspto-grants-2007_02
- 특허 번호
- US07179801B2
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