Ethyl formate → 2-(2,3-dihydro-1H-imidazo[1,2-b]pyrazol-7-yl)ethylformamide

HRID 349571노트

반응식

HRID 349571 반응식
[NH:1]1[C:8]2[N:4]([N:5]=[CH:6][C:7]=2[CH2:9][CH2:10][NH2:11])[CH2:3][CH2:2]1.[CH:12](OCC)=[O:13]>>[NH:1]1[C:8]2[N:4]([N:5]=[CH:6][C:7]=2[CH2:9][CH2:10][NH:11][CH:12]=[O:13])[CH2:3][CH2:2]1

참가 물질

3

반응물 2

HCID 8025Ethyl formateHCID 1357327622-(2,3-Dihydro-1H-imidazo[1,2-b]pyrazol-7-yl)ethanamine

생성물 1

HCID 1363341052-(2,3-dihydro-1H-imidazo[1,2-b]pyrazol-7-yl)ethylformamide

실험 절차

A suspension of 2-(2,3-dihydro-1H-imidazo[1,2-b]pyrazol-7-yl)ethylamine (155 mg) in ethyl formate (3 ml) was refluxed for 4.5 hours. After evaporation of the solvent in vacuo, the residue was triturated with ethyl acetate and dried in vacuo to give 2-(2,3-dihydro-1H-imidazo[1,2-b]pyrazol-7-yl)ethylformamide (165 mg) as a solid.

후처리

  1. temperaturewas refluxed for 4.5 hours
  2. customAfter evaporation of the solvent in vacuo
  3. customthe residue was triturated with ethyl acetate
  4. customdried in vacuo

출처 및 근거

ORD 기록
ord-20db1619b3a544cd8dc99178597891e5
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07179801B2

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