Sodium borohydride → 4-FLUORO-N-[5-(1-HYDROXY-ETHYL)-INDAN-2-yl]-BENZAMIDE

HRID 349589노트

반응식

HRID 349589 반응식
[C:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[CH2:9][CH:8]([NH:13][C:14](=[O:22])[C:15]1[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=1)[CH2:7]2)(=[O:3])[CH3:2].[BH4-].[Na+]>CO>[F:21][C:18]1[CH:17]=[CH:16][C:15]([C:14]([NH:13][CH:8]2[CH2:7][C:6]3[C:10](=[CH:11][CH:12]=[C:4]([CH:1]([OH:3])[CH3:2])[CH:5]=3)[CH2:9]2)=[O:22])=[CH:20][CH:19]=1

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 21920974N-(5-Acetyl-indan-2-YL)-4-fluoro-benzamide

생성물 1

HCID 219211674-FLUORO-N-[5-(1-HYDROXY-ETHYL)-INDAN-2-yl]-BENZAMIDE

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

400 mg (1.35 mmol) N-(5-acetyl-indan-2-yl)-4-fluoro-benzamide were dissolved in 10 ml of methanol, then 100 mg (2.7 mmol) sodium borohydride were added. The mixture was worked up by dropping onto ice/HCl, the resulting solid was filtered off.

후처리

  1. filtrationthe resulting solid was filtered off

출처 및 근거

ORD 기록
ord-b47f8740bf074cc5b8dafa3f5c0aa5c0
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07179839B2

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