Hydroxyamine hydrochloride → 2-((Hydroxyimino)methyl)-5-morpholin-4-yl-phenol

HRID 349685

반응식

HRID 349685 반응식
[OH:1][C:2]1[CH:9]=[C:8]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)[CH:7]=[CH:6][C:3]=1[CH:4]=O.Cl.[NH2:17][OH:18]>N1C=CC=CC=1>[OH:18][N:17]=[CH:4][C:3]1[CH:6]=[CH:7][C:8]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)=[CH:9][C:2]=1[OH:1]

참가 물질

4

반응물 2

HCID 443297Hydroxyamine hydrochlorideHCID 98156592-Hydroxy-4-morpholin-4-yl-benzaldehyde

생성물 1

HCID 1363488032-((Hydroxyimino)methyl)-5-morpholin-4-yl-phenol수율 35.3%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

A solution of 2-hydroxy-4-morpholin-4-yl-ben zaldehyde (0.135 g, 0.65 mmol) in pyridine (5 mL) was treated with hydroxylamine hydrochloride (45 mg, 0.65 mmol) and stirred for 30 min at room temperature. The reaction mixture was concentrated in vacuo and the residue was partitioned between EtOAc and 5% sodium bicarbonate. The organic layer was dried over Na2SO4 and concentrated in vacuo to afford the product as a pale yellow solid (51 mg, 35%).

후처리

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customthe residue was partitioned between EtOAc and 5% sodium bicarbonate
  3. dry with materialThe organic layer was dried over Na2SO4
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-2933d28a5b0046e8a6b1317020a98505
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07179912B2

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