Hydroxyamine hydrochloride → 2-((Hydroxyimino)methyl)-5-morpholin-4-yl-phenol
반응식
[OH:1][C:2]1[CH:9]=[C:8]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)[CH:7]=[CH:6][C:3]=1[CH:4]=O.Cl.[NH2:17][OH:18]>N1C=CC=CC=1>[OH:18][N:17]=[CH:4][C:3]1[CH:6]=[CH:7][C:8]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)=[CH:9][C:2]=1[OH:1]참가 물질
4
실험 절차
A solution of 2-hydroxy-4-morpholin-4-yl-ben zaldehyde (0.135 g, 0.65 mmol) in pyridine (5 mL) was treated with hydroxylamine hydrochloride (45 mg, 0.65 mmol) and stirred for 30 min at room temperature. The reaction mixture was concentrated in vacuo and the residue was partitioned between EtOAc and 5% sodium bicarbonate. The organic layer was dried over Na2SO4 and concentrated in vacuo to afford the product as a pale yellow solid (51 mg, 35%).
후처리
- concentrationThe reaction mixture was concentrated in vacuo
- customthe residue was partitioned between EtOAc and 5% sodium bicarbonate
- dry with materialThe organic layer was dried over Na2SO4
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-2933d28a5b0046e8a6b1317020a98505
- 출처 데이터셋
- uspto-grants-2007_02
- 특허 번호
- US07179912B2
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