Sulfuric Acid → N-(2-fluoro-5-nitrophenyl)acetamide

HRID 349732노트

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HRID 349732 반응식
[F:1][C:2]1[CH:8]=[CH:7][C:6]([N+:9]([O-:11])=[O:10])=[CH:5][C:3]=1[NH2:4].[C:12](OC(=O)C)(=[O:14])[CH3:13].S(=O)(=O)(O)O>>[F:1][C:2]1[CH:8]=[CH:7][C:6]([N+:9]([O-:11])=[O:10])=[CH:5][C:3]=1[NH:4][C:12](=[O:14])[CH3:13]

참가 물질

4

반응물 3

HCID 1118Sulfuric AcidHCID 7918Acetic AnhydrideHCID 677852-Fluoro-5-nitroaniline

생성물 1

HCID 2779405N-(2-fluoro-5-nitrophenyl)acetamide

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온도
100 °C

실험 절차

5.0 g (32 mmol) of 2-fluoro-5-nitroaniline were admixed with 10 ml (110 mmol) of acetic anhydride and 0.1 ml of conc. sulfuric acid and stirred at 100° C. for 1.5 hours. The solution was added to 100 ml of ice/water, and the precipitate which formed was filtered off and washed with water. The crude product was purified by chromatography (1:1 ethyl acetate/heptane) on silica gel (yield 5.4 g, 85%).

후처리

  1. customthe precipitate which formed
  2. filtrationwas filtered off
  3. washwashed with water
  4. customThe crude product was purified by chromatography (1:1 ethyl acetate/heptane) on silica gel (yield 5.4 g, 85%)

출처 및 근거

ORD 기록
ord-6b7a628752e0486c983fa8a366d0a4b0
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07179941B2

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