Ethyl 6-fluoroimidazo[1,2-a]pyridine-2-carboxylate → 6-Fluoroimidazo[1,2-a]pyridine-2-carboxylic acid

HRID 349749노트

반응식

HRID 349749 반응식
C([O:3][C:4]([C:6]1[N:7]=[C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][N:9]2[CH:15]=1)=[O:5])C>Cl>[F:14][C:11]1[CH:12]=[CH:13][C:8]2[N:9]([CH:15]=[C:6]([C:4]([OH:5])=[O:3])[N:7]=2)[CH:10]=1

참가 물질

3

반응물 1

HCID 40148106Ethyl 6-fluoroimidazo[1,2-a]pyridine-2-carboxylate

생성물 1

HCID 223975086-Fluoroimidazo[1,2-a]pyridine-2-carboxylic acid수율 99.4%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

A solution of 6-fluoro-imidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester (1 g) in 4N HCl was refluxed for 4 hours. The solvent was evaporated to give the sub-title compound as a white solid (0.86 g).

후처리

  1. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-e8f5b0311ce24dd691c9567f21cc66f2
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07179922B2

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