Acetone → 3-Piperidinopropiophenone hydrochloride
반응식
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)(=[O:3])[CH3:2].[ClH:10].[NH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1.C=O.[CH3:19]C(C)=O>C(O)C>[ClH:10].[N:11]1([CH2:19][CH2:2][C:1]([C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=2)=[O:3])[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1참가 물질
6
실험 절차
A mixture of 120 g of acetophenone, 133 g of piperidine hydrochloride and 50 g of paraformaldehyde in 120 ml of ethanol was refluxed for 6 hours. The mixture was then allowed to stand for cooling to soldify. The resulting solid was crushed after addition of 400 ml of acetone, and then collected by filtration. The collected solid was washed successively with acetone and hexane and dried to obtain 191.6 g (yield: 75.4%) of the subject compound as a white scaly product.
후처리
- temperaturewas refluxed for 6 hours
- temperaturefor cooling
- customThe resulting solid was crushed
- filtrationcollected by filtration
- washThe collected solid was washed successively with acetone and hexane
- customdried
출처 및 근거
- ORD 기록
- ord-2a8bdce2894f4e98a5de81fcefcaeafc
- 출처 데이터셋
- uspto-grants-1988_08
- 특허 번호
- US04764617
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