Acetone → 3-Piperidinopropiophenone hydrochloride

HRID 35011

반응식

HRID 35011 반응식
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)(=[O:3])[CH3:2].[ClH:10].[NH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1.C=O.[CH3:19]C(C)=O>C(O)C>[ClH:10].[N:11]1([CH2:19][CH2:2][C:1]([C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=2)=[O:3])[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1

참가 물질

6

반응물 4

HCID 180AcetoneHCID 712FormaldehydeHCID 7410AcetophenoneHCID 2723721Piperidine, hydrochloride (1:1)

생성물 1

HCID 701713-Piperidinopropiophenone hydrochloride수율 75.4%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 120 g of acetophenone, 133 g of piperidine hydrochloride and 50 g of paraformaldehyde in 120 ml of ethanol was refluxed for 6 hours. The mixture was then allowed to stand for cooling to soldify. The resulting solid was crushed after addition of 400 ml of acetone, and then collected by filtration. The collected solid was washed successively with acetone and hexane and dried to obtain 191.6 g (yield: 75.4%) of the subject compound as a white scaly product.

후처리

  1. temperaturewas refluxed for 6 hours
  2. temperaturefor cooling
  3. customThe resulting solid was crushed
  4. filtrationcollected by filtration
  5. washThe collected solid was washed successively with acetone and hexane
  6. customdried

출처 및 근거

ORD 기록
ord-2a8bdce2894f4e98a5de81fcefcaeafc
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04764617

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