3-Benzyloxy-4-methoxypicolinic acid → 3-Hydroxy-4-methoxypyridine-2-carboxylic acid

HRID 350651

반응식

HRID 350651 반응식
C([O:8][C:9]1[C:10]([C:17]([OH:19])=[O:18])=[N:11][CH:12]=[CH:13][C:14]=1[O:15][CH3:16])C1C=CC=CC=1>C(O)C.[C].[Pd]>[OH:8][C:9]1[C:10]([C:17]([OH:19])=[O:18])=[N:11][CH:12]=[CH:13][C:14]=1[O:15][CH3:16]

참가 물질

4

반응물 1

HCID 199602893-Benzyloxy-4-methoxypicolinic acid

생성물 1

HCID 110411213-Hydroxy-4-methoxypyridine-2-carboxylic acid수율 81.6%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 702Ethanol용매

실험 절차

3-Benzyloxy-4-methoxypicolinic acid (5.3 g) was suspended in 25 ml of ethanol. 10% palladium-carbon (0.5 g) was added to the suspension. The mixture was then catalytically hydrogenated under atmospheric pressure for 30 min. The reaction solution was filtered under the reduced pressure. The filtrate was concentrated under the reduced pressure to give 2.8 g (yield 81.6%) of the title compound as colorless powder.

후처리

  1. filtrationThe reaction solution was filtered under the reduced pressure
  2. concentrationThe filtrate was concentrated under the reduced pressure

출처 및 근거

ORD 기록
ord-fdccc608141d4e1c8f6a5004e9b1d6cb
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07183278B1

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