Hydrochloric Acid → 3-Hydroxy-4-methoxypicolinic acid hydrochloride

HRID 350652

반응식

HRID 350652 반응식
C([O:8][C:9]1[C:10]([C:17]([OH:19])=[O:18])=[N:11][CH:12]=[CH:13][C:14]=1[O:15][CH3:16])C1C=CC=CC=1.[ClH:20]>CO>[ClH:20].[OH:8][C:9]1[C:10]([C:17]([OH:19])=[O:18])=[N:11][CH:12]=[CH:13][C:14]=1[O:15][CH3:16]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 199602893-Benzyloxy-4-methoxypicolinic acid

생성물 1

HCID 694976023-Hydroxy-4-methoxypicolinic acid hydrochloride수율 54.8%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

3-Benzyloxy-4-methoxypicolinic acid (8.3 g) was dissolved in 100 ml of methanol. Concentrated hydrochloric acid (2 ml) was added to the solution. The mixture was heated under reflux for 30 min. The reaction solution was concentrated under the reduced pressure. The residue was recrystallized from water-ethanol to give 3.6 g (yield 54.8%) of title compound as colorless powder.

후처리

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 30 min
  3. concentrationThe reaction solution was concentrated under the reduced pressure
  4. customThe residue was recrystallized from water-ethanol

출처 및 근거

ORD 기록
ord-a78ece4b9afc480db0193fba1d565803
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07183278B1

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