Hydrochloric Acid → methyl 5-bromo-1H-indole-2-carboxylate

HRID 350824

반응식

HRID 350824 반응식
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:11]([OH:13])=[O:12])=[CH:5]2.Cl.[CH3:15]O>>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:11]([O:13][CH3:15])=[O:12])=[CH:5]2

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 2521375-Bromo-1H-indole-2-carboxylic acid

생성물 1

HCID 914343methyl 5-bromo-1H-indole-2-carboxylate

실험 절차

A solution of 5-Bromo-1H-indole-2-carboxylic acid (commercial, 10.0 g, 41.6 mmol) in methanol (200 ml) was cooled to 0° C. and saturated with HCl (g). The resulting solution was allowed to warm gradually to room temperature overnight. The solvent was removed in vacuo and the residue treated with 0.88 ammonia (500 ml). The resulting solution was extracted with dichloromethane (3-fold 150 ml) and the combined organics dried (magnesium sulphate) and the solvent removed in vacuo to give the required product as a colourless oil (8.35 g).

후처리

  1. customThe solvent was removed in vacuo
  2. additionthe residue treated with 0.88 ammonia (500 ml)
  3. extractionThe resulting solution was extracted with dichloromethane (3-fold 150 ml)
  4. dry with materialthe combined organics dried (magnesium sulphate)
  5. customthe solvent removed in vacuo

출처 및 근거

ORD 기록
ord-6e23edc77f854fb0a5ce3f14c9c8efb3
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07183294B2

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