Sodium Hydroxide → 3-(3-Phenylsulfamoylphenyl)acrylic acid

HRID 351030노트

반응식

HRID 351030 반응식
C[O:2][C:3](=[O:22])[CH:4]=[CH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([S:12](=[O:21])(=[O:20])[NH:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:7]=1.[OH-].[Na+]>CO>[C:14]1([NH:13][S:12]([C:8]2[CH:7]=[C:6]([CH:5]=[CH:4][C:3]([OH:22])=[O:2])[CH:11]=[CH:10][CH:9]=2)(=[O:21])=[O:20])[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 67019508Methyl 3-[3-(phenylsulfamoyl)phenyl]prop-2-enoate

생성물 1

HCID 670195203-(3-Phenylsulfamoylphenyl)acrylic acid수율 82.7%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

3-(3-Phenylsulfamoylphenyl)acrylic acid methyl ester (4a) (0.220 g, 0.69 mmol) was dissolved in methanol (3 ml), 1N NaOH (2.08 ml, 2.08 mmol) was added and the resultant solution was stirred at ambient temperature overnight. The reaction mixture was partitioned between ethyl acetate and water. The aqueous layer was acidified with 10% HCl and stirred for 30 min. The precipitated solid was filtered, washed with water and dried in desiccator over P2O5 to give the title compound as a white solid (0.173 g, 82%).

후처리

  1. customThe reaction mixture was partitioned between ethyl acetate and water
  2. filtrationThe precipitated solid was filtered
  3. washwashed with water
  4. dry with materialdried in desiccator over P2O5

출처 및 근거

ORD 기록
ord-042e572164214f4ea9bb08c242c4536f
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07183298B2

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