Sodium Hydroxide → 1152534-54-7

HRID 351242노트

반응식

HRID 351242 반응식
[OH-].[Na+].NC(NCCOC1C=CC([C:16]2[N:20]([C:21]3[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][CH:22]=3)[N:19]=[C:18]([C:29]([O:31]CC)=[O:30])[CH:17]=2)=CC=1)=O>C1COCC1.CO>[CH3:28][O:27][C:24]1[CH:23]=[CH:22][C:21]([N:20]2[CH:16]=[CH:17][C:18]([C:29]([OH:31])=[O:30])=[N:19]2)=[CH:26][CH:25]=1

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 21091020HCID 21091020, 화합물

생성물 1

HCID 289740221152534-54-7수율 175.6%

시약·촉매·용매 2

HCID 887Methanol용매HCID 8028Tetrahydrofuran용매

실험 절차

1M NaOH (5 ml) was added to a solution of ethyl 5-(4-{2-[(aminocarbonyl)amino]ethoxy}phenyl)-1-(4-methoxyphenyl)-1H-pyrazole-3-carboxylate (1.75 g) in THF (15 ml) and MeOH (10 ml). The reaction mixture was stirred at ambient temperature and concentrated in vacuo. The residue was dissolved in H2O and acidified by 1M HCl. white precipitates were collected and washed successively with H2O and IPE to give 5-(4–12-[(aminocarbonyl)amino]-ethoxy}phenyl)-1-(4-methoxyphenyl)-1H-pyrazole-3-carboxylic acid (1.58 g) as a white powder.

후처리

  1. concentrationconcentrated in vacuo
  2. dissolutionThe residue was dissolved in H2O
  3. customwhite precipitates
  4. customwere collected
  5. washwashed successively with H2O and IPE

출처 및 근거

ORD 기록
ord-e9e3eccaf01242d29f5fdba52ad742b2
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07183306B2

반응 노트

불러오는 중…