Sodium Hydroxide → 2-Methoxy-3-nitrobenzoic acid

HRID 351343노트

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HRID 351343 반응식
[OH-].[Na+].[CH3:3][O:4][C:5]1[C:14]([N+:15]([O-:17])=[O:16])=[CH:13][CH:12]=[CH:11][C:6]=1[C:7]([O:9]C)=[O:8]>CO>[CH3:3][O:4][C:5]1[C:14]([N+:15]([O-:17])=[O:16])=[CH:13][CH:12]=[CH:11][C:6]=1[C:7]([OH:9])=[O:8]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 590805Methyl 2-methoxy-3-nitrobenzoate

생성물 1

HCID 120151952-Methoxy-3-nitrobenzoic acid수율 94.3%

시약·촉매·용매 1

HCID 887Methanol용매

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온도
50 °C

실험 절차

1N Sodium hydroxide was added to a solution (50 ml) of methyl 2-methoxy-3-nitrobenzoate (4.96 g, 23.5 mmol) in methanol and the mixture was stirred at 50° C. for 2 hrs. Methanol was evaporated under reduced pressure and water was added. The aqueous layer was acidified with 1N hydrochloric acid, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, and dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The obtained residue was recrystallized from hexane-ethyl acetate to give the title compound (4.37 g) as pale-yellow crystals. melting point: 224–226° C.

후처리

  1. customMethanol was evaporated under reduced pressure and water
  2. additionwas added
  3. extractionthe mixture was extracted with ethyl acetate
  4. washThe organic layer was washed with saturated brine
  5. dry with materialdried over anhydrous magnesium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated under reduced pressure
  8. customThe obtained residue was recrystallized from hexane-ethyl acetate

출처 및 근거

ORD 기록
ord-32a364d3ba2d434ca707fb8ad0c8b738
출처 데이터셋
uspto-grants-2007_02
특허 번호
US07183415B2

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