Potassium Carbonate → Diethyl-2-[4'-(4"-cyano-phenoxy)-phenoxy]-propionyl-malonate

HRID 35146

반응식

HRID 35146 반응식
[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1O)#[N:2].[CH2:10]([O:12][C:13](=[O:32])[CH:14]([C:20](=[O:31])[CH:21]([O:23][C:24]1[CH:29]=[CH:28][C:27](F)=[CH:26][CH:25]=1)[CH3:22])[C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH3:11].C(=O)([O-])[O-:34].[K+].[K+]>CS(C)=O>[CH2:10]([O:12][C:13](=[O:32])[CH:14]([C:20](=[O:31])[CH:21]([O:23][C:24]1[CH:29]=[CH:28][C:27]([O:34][C:6]2[CH:7]=[CH:8][C:3]([C:1]#[N:2])=[CH:4][CH:5]=2)=[CH:26][CH:25]=1)[CH3:22])[C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH3:11]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 119072-HydroxybenzonitrileHCID 23037018Diethyl-2-(4'-fluoro-phenoxy)-propionyl-malonate

생성물 1

HCID 21295006Diethyl-2-[4'-(4"-cyano-phenoxy)-phenoxy]-propionyl-malonate수율 86%

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

반응 조건

온도
60 °C

실험 절차

11.9 g of cyano-phenol and 32.6 g of diethyl-2-(4'-fluoro-phenoxy)-propionyl-malonate are dissolved in 150 ml of dimethyl sulfoxide, whereupon 13.8 g of potassium carbonate are added and the reaction mixture is stirred at 60° C. for 6 hours. The reaction mixture is filtered and the filtrate is evaporated. Thus 36 g of the desired compound are obtained, yield 86%.

후처리

  1. additionare added
  2. filtrationThe reaction mixture is filtered
  3. customthe filtrate is evaporated

출처 및 근거

ORD 기록
ord-39eba38794a340b28f97b842753e7fc2
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04765825

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