Triethylamine → 1-[4-[4-(4-Hexyloxyphenyl)piperazin-1-yl]benzoyloxy]benzotriazole

HRID 351553노트

반응식

HRID 351553 반응식
[OH:1][N:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[N:4]=[N:3]1.Cl.[CH2:12]([O:18][C:19]1[CH:24]=[CH:23][C:22]([N:25]2[CH2:30][CH2:29][N:28]([C:31]3[CH:39]=[CH:38][C:34]([C:35](O)=[O:36])=[CH:33][CH:32]=3)[CH2:27][CH2:26]2)=[CH:21][CH:20]=1)[CH2:13][CH2:14][CH2:15][CH2:16][CH3:17].C(N(CC)CC)C.Cl.C(N=C=NCCCN(C)C)C>O.ClCCl>[CH2:12]([O:18][C:19]1[CH:20]=[CH:21][C:22]([N:25]2[CH2:26][CH2:27][N:28]([C:31]3[CH:39]=[CH:38][C:34]([C:35]([O:1][N:2]4[C:6]5[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=5[N:4]=[N:3]4)=[O:36])=[CH:33][CH:32]=3)[CH2:29][CH2:30]2)=[CH:23][CH:24]=1)[CH2:13][CH2:14][CH2:15][CH2:16][CH3:17]

참가 물질

7

반응물 4

HCID 8471TriethylamineHCID 757711-HydroxybenzotriazoleHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 698180334-[4-(4-Hexyloxyphenyl)piperazin-1-yl]benzoic acid hydrochloride

생성물 1

HCID 227132451-[4-[4-(4-Hexyloxyphenyl)piperazin-1-yl]benzoyloxy]benzotriazole수율 93.8%

시약·촉매·용매 2

HCID 962Water용매HCID 6344Dichloromethane용매

실험 절차

To a solution of 1-hydroxybenzotriazole (5.35 g) and 4-[4-(4-hexyloxyphenyl)piperazin-1-yl]benzoic acid hydrochloride (15 g) in the mixture of triethylamine (9.64 ml) and dichloromethane (450 ml) was added 1-ethyl-3-(3′-dimethylaminopropyl) carbodiimide hydrochloride (WSCD.HCl) (12.6 g) and stirred for 4 hours at ambient temperature. The reaction mixture was added to water. The organic layer was taken and dried over magnesium sulfate. Magnesium sulfate was filtered off, and the filtrate was evaporated under reduced pressure to give 1-[4-[4-(4-hexyloxyphenyl)piperazin-1-yl]benzoyloxy]benzotriazole (16.78 g).

후처리

  1. dry with materialdried over magnesium sulfate
  2. filtrationMagnesium sulfate was filtered off
  3. customthe filtrate was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-1394ded476814c2bb9f1ccf9d009a025
출처 데이터셋
uspto-grants-2004_06
특허 번호
US06743776B2

반응 노트

불러오는 중…