Ethyl methanesulfonylacetate → Ethyl 3-dimethylamino-2-methylsulphonylacrylate

반응식

[CH3:1][S:2]([CH2:5][C:6]([O:8][CH2:9][CH3:10])=[O:7])(=[O:4])=[O:3].CO[CH:13](OC)[N:14]([CH3:16])[CH3:15]>>[CH3:13][N:14]([CH3:16])[CH:15]=[C:5]([S:2]([CH3:1])(=[O:4])=[O:3])[C:6]([O:8][CH2:9][CH3:10])=[O:7]

참가 물질

반응물 2

HCID 78201Ethyl methanesulfonylacetate

HCID 78373Dimethylformamide dimethyl acetal

생성물 1

HCID 57126670Ethyl 3-dimethylamino-2-methylsulphonylacrylate

반응 조건

온도: 85 °C

실험 절차

6.65 g (40 mmol) of ethyl methanesulphonylacetate and 5.72 g (48 mmol) of N,N-dimethylformamide dimethyl acetal are admixed and heated at 85° C. overnight. The solution is concentrated using a rotary evaporator, and the solid is comminuted with cyclohexane and filtered off with suction.

후처리

concentrationThe solution is concentrated
customa rotary evaporator
customthe solid is comminuted with cyclohexane
filtrationfiltered off with suction

출처 및 근거

ORD 기록: ord-d5b98d3c965f4e9796d425aac5851886
출처 데이터셋: uspto-grants-2004_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06743798B1

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