Ethyl methanesulfonylacetate → Ethyl 3-dimethylamino-2-methylsulphonylacrylate

HRID 351653

반응식

HRID 351653 반응식
[CH3:1][S:2]([CH2:5][C:6]([O:8][CH2:9][CH3:10])=[O:7])(=[O:4])=[O:3].CO[CH:13](OC)[N:14]([CH3:16])[CH3:15]>>[CH3:13][N:14]([CH3:16])[CH:15]=[C:5]([S:2]([CH3:1])(=[O:4])=[O:3])[C:6]([O:8][CH2:9][CH3:10])=[O:7]

참가 물질

3

반응물 2

HCID 78201Ethyl methanesulfonylacetateHCID 78373Dimethylformamide dimethyl acetal

생성물 1

HCID 57126670Ethyl 3-dimethylamino-2-methylsulphonylacrylate

반응 조건

온도
85 °C

실험 절차

6.65 g (40 mmol) of ethyl methanesulphonylacetate and 5.72 g (48 mmol) of N,N-dimethylformamide dimethyl acetal are admixed and heated at 85° C. overnight. The solution is concentrated using a rotary evaporator, and the solid is comminuted with cyclohexane and filtered off with suction.

후처리

  1. concentrationThe solution is concentrated
  2. customa rotary evaporator
  3. customthe solid is comminuted with cyclohexane
  4. filtrationfiltered off with suction

출처 및 근거

ORD 기록
ord-d5b98d3c965f4e9796d425aac5851886
출처 데이터셋
uspto-grants-2004_06
특허 번호
US06743798B1

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