3-Bromoquinoline → HCID 10226356, 화합물

HRID 351738

반응식

HRID 351738 반응식
[C:1]1([C:7](O)([C:9]#C)C)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Br[C:13]1[CH:14]=[N:15][C:16]2[C:21]([CH:22]=1)=[CH:20][CH:19]=[CH:18][CH:17]=2.[CH:23]([NH:26][C:27]([C:29]1[C:38](=[O:39])[C:37]2[C:32](=[N:33][CH:34]=[CH:35][CH:36]=2)[N:31](C2C=CC=C(Br)C=2)[CH:30]=1)=[O:28])([CH3:25])[CH3:24]>>[CH:23]([NH:26][C:27]([C:29]1[C:38](=[O:39])[C:37]2[C:32](=[N:33][CH:34]=[CH:35][CH:36]=2)[N:31]([C:5]2[CH:4]=[CH:3][CH:2]=[C:1]([C:7]#[C:9][C:13]3[CH:14]=[N:15][C:16]4[C:21]([CH:22]=3)=[CH:20][CH:19]=[CH:18][CH:17]=4)[CH:6]=2)[CH:30]=1)=[O:28])([CH3:25])[CH3:24]

참가 물질

4

반응물 3

HCID 214133-BromoquinolineHCID 920983-Hydroxy-3-phenyl-1-butyneHCID 129913181-(3-bromophenyl)-N-isopropyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide

생성물 1

HCID 10226356HCID 10226356, 화합물

실험 절차

Following the procedure of EXAMPLE 15, but substituting N-isopropyl-1-(3-ethynylphenyl)-1,4-dihydro[1,8]naphthyridin-4-one-3-carboxamide from Step 2 of EXAMPLE 5 for 2-phenyl-3-butyn-2-ol, and 3-bromoquinoline for N-isopropyl-1-(3-bromophenyl)-1,4-dihydro[1,8]naphthyridin-4-one-3-carboxamide, the title compound was obtained as a solid.

출처 및 근거

ORD 기록
ord-058daf43f4e44aa88f5ef26b42ef0cd2
출처 데이터셋
uspto-grants-2004_06
특허 번호
US06743802B2

연결된 노트

불러오는 중…