Trimethylsilylacetylene → 5-(1-Hydroxy-1-methylethyl)-2-[(trimethylsilyl)ethynyl]pyridine

HRID 351745

반응식

HRID 351745 반응식
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([OH:11])([CH3:10])[CH3:9])=[CH:4][N:3]=1.C(NC(C1C(=O)C2C(=NC=CC=2)N(C2C=CC=C(Br)C=2)C=1)=O)(C)C.[CH3:36][Si:37]([C:40]#[CH:41])([CH3:39])[CH3:38].C1(C(O)(C#C)C)C=CC=CC=1>>[OH:11][C:8]([C:5]1[CH:6]=[CH:7][C:2]([C:41]#[C:40][Si:37]([CH3:39])([CH3:38])[CH3:36])=[N:3][CH:4]=1)([CH3:10])[CH3:9]

참가 물질

5

반응물 4

HCID 66111TrimethylsilylacetyleneHCID 920983-Hydroxy-3-phenyl-1-butyneHCID 129913181-(3-bromophenyl)-N-isopropyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamideHCID 223919732-(6-Bromo-3-pyridyl)-2-propanol

생성물 1

HCID 227142995-(1-Hydroxy-1-methylethyl)-2-[(trimethylsilyl)ethynyl]pyridine

실험 절차

Following the procedure of EXAMPLE 15, but substituting the product 2-bromo-5-(1-hydroxy-1-methylethyl)pyridine from present Step 1 for N-isopropyl-1-(3-bromophenyl)-1,4-dihydro[1,8]naphthyridin-4-one-3-carboxamide and trimethylsilylacetylene for 2-phenyl-3-butyn-2-ol, the 5-(1-hydroxy-1-methylethyl)-2-[(trimethylsilyl)ethynyl]pyridine compound was obtained.

출처 및 근거

ORD 기록
ord-822a8419b4af419f81bb282333b1a4ee
출처 데이터셋
uspto-grants-2004_06
특허 번호
US06743802B2

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