O-(Trimethylsilyl)hydroxylamine → HCID 178474861, 화합물

HRID 351881

반응식

HRID 351881 반응식
C[Si](C)(C)[O:3][NH2:4].[C:7]([NH:10][CH2:11][C@@H:12]1[O:16][C:15](=[O:17])[N:14]([C:18]2[CH:23]=[CH:22][C:21]([C:24]#[N:25])=[C:20]([F:26])[CH:19]=2)[CH2:13]1)(=[O:9])[CH3:8]>C(O)C>[C:7]([NH:10][CH2:11][C@@H:12]1[O:16][C:15](=[O:17])[N:14]([C:18]2[CH:23]=[CH:22][C:21]([C:24](=[NH:25])[NH:4][OH:3])=[C:20]([F:26])[CH:19]=2)[CH2:13]1)(=[O:9])[CH3:8]

참가 물질

4

반응물 2

HCID 2734666O-(Trimethylsilyl)hydroxylamineHCID 229661895-(S)-acetamidomethyl-3-[4'-cyano-3'-fluorophenyl]oxazolidine-2-one

생성물 1

HCID 178474861HCID 178474861, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

O-Trimethylsilylhydroxylamine (0.37 ml, 3.0 mmol) and 5-(S)-acetamidomethyl-3-[4′-cyano-3′-fluorophenyl]oxazolidine-2-one (0.277 g, 1.0 mmol) in ethanol (3.0 ml) were stirred at 80° C. in a sealed reaction vial for 2.5 h. The mixture was left at r.t. for 48 h, and the crystallized product filtered, rinsed with ethanol (ca. 0.75 ml), washed with ether, and dried under vacuum. Yellow crystals. Yield 0.260 g (84%). HPLC: Rt 2.6 min. MS (m/z): [M+H]+=311.

후처리

  1. filtrationthe crystallized product filtered
  2. washrinsed with ethanol (ca. 0.75 ml)
  3. washwashed with ether
  4. customdried under vacuum

출처 및 근거

ORD 기록
ord-340c4767b10a46debfb353ea1607ee36
출처 데이터셋
uspto-grants-2004_06
특허 번호
US06743811B2

연결된 노트

불러오는 중…