Potassium Carbonate → HCID 15549282, 화합물

HRID 351926

반응식

HRID 351926 반응식
[C:1]1([CH:7]([C:14]2[C:22]3[C:17](=[CH:18][C:19]([OH:23])=[CH:20][CH:21]=3)[NH:16][CH:15]=2)[CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Br[CH2:25][CH2:26][CH2:27][OH:28].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[C:1]1([CH:7]([C:14]2[C:22]3[C:17](=[CH:18][C:19]([O:23][CH2:25][CH2:26][CH2:27][OH:28])=[CH:20][CH:21]=3)[NH:16][CH:15]=2)[CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 123083-Bromo-1-propanolHCID 15549281Ethyl 3-phenyl-3-(6-hydroxyindol-3-yl)propionate

생성물 1

HCID 15549282HCID 15549282, 화합물

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

1.2 g (3.88 mmol) of 4 are refluxed overnight in 30 ml of acetone together with 0.66 ml (7.6 mmol) of 3-bromo-1-propanol and 2.1 g (15.2 mmol) of potassium carbonate. After cooling, the insoluble residue is filtered off, and the filtrate is evaporated. The crude product can be purified by chromatography on silica gel (eluent gradient toluene/acetone 9:1→4:1), giving ethyl 3-phenyl-3-[6-(3-hydroxypropoxy)indol-3-yl]propionate.

후처리

  1. temperatureAfter cooling
  2. filtrationthe insoluble residue is filtered off
  3. customthe filtrate is evaporated
  4. customThe crude product can be purified by chromatography on silica gel (eluent gradient toluene/acetone 9:1→4:1)

출처 및 근거

ORD 기록
ord-65df8d02bc2e4336aa6a4165735b371b
출처 데이터셋
uspto-grants-2004_06
특허 번호
US06743810B2

연결된 노트

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