Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → Ethyl 3-phenyl-3-[6-(3-hydroxypropoxy)indol-3-yl]propionate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 3-Bromo-1-propanol | HCID 12308 | — |
| 반응물 | Ethyl 3-phenyl-3-(6-hydroxyindol-3-yl)propionate | HCID 15549281 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | Ethyl 3-phenyl-3-[6-(3-hydroxypropoxy)indol-3-yl]propionate | HCID 15549282 | — |
반응 단계
1.2 g (3.88 mmol) of 4 are refluxed overnight in 30 ml of acetone together with 0.66 ml (7.6 mmol) of 3-bromo-1-propanol and 2.1 g (15.2 mmol) of potassium carbonate. After cooling, the insoluble residue is filtered off, and the filtrate is evaporated. The crude product can be purified by chromatography on silica gel (eluent gradient toluene/acetone 9:1→4:1), giving ethyl 3-phenyl-3-[6-(3-hydroxypropoxy)indol-3-yl]propionate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06743810B2 |
| 출처 데이터셋 | uspto-grants-2004_06 |
| ORD ID | ord-65df8d02bc2e4336aa6a4165735b371b |
| 출처 메모 | uspto-grants-2004_06 |