Methyl 2-(3-pyridylmethyl)naphthalene-6-carboxylate hydrochloride → 2-(3-Pyridylmethyl)naphthalene-6-carboxylic acid hydrochloride

HRID 35195노트

반응식

HRID 35195 반응식
[ClH:1].[N:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH2:8][C:9]2[CH:18]=[CH:17][C:16]3[C:11](=[CH:12][CH:13]=[C:14]([C:19]([O:21]C)=[O:20])[CH:15]=3)[CH:10]=2)[CH:3]=1>Cl>[ClH:1].[N:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH2:8][C:9]2[CH:18]=[CH:17][C:16]3[C:11](=[CH:12][CH:13]=[C:14]([C:19]([OH:21])=[O:20])[CH:15]=3)[CH:10]=2)[CH:3]=1

참가 물질

3

반응물 1

HCID 21295725Methyl 2-(3-pyridylmethyl)naphthalene-6-carboxylate hydrochloride

생성물 1

HCID 704078322-(3-Pyridylmethyl)naphthalene-6-carboxylic acid hydrochloride

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

A solution of 205 mg of methyl 2-(3-pyridylmethyl)naphthalene-6-carboxylate hydrochloride in 15 ml of 6N hydrochloric acid was refluxed for 18 hours. The solution was cooled to room temperature and the precipitate filtered off, washed with cold 6N hydrochloric acid followed by acetone and air dried to give 2-(3-pyridylmethyl)naphthalene-6-carboxylic acid hydrochloride, m.p. 265°-270° C.

후처리

  1. filtrationthe precipitate filtered off
  2. washwashed with cold 6N hydrochloric acid
  3. customdried

출처 및 근거

ORD 기록
ord-c5f8d1cfcb224e08b8051b532a91ee86
출처 데이터셋
uspto-grants-1988_08
특허 번호
US04766127

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