Dichloroacetaldehyde → 2,2-Dichloroacetaldehyde tosylhydrazone
반응식
[S:1]([NH:11][NH2:12])([C:4]1[CH:10]=[CH:9][C:7]([CH3:8])=[CH:6][CH:5]=1)(=[O:3])=[O:2].[Cl:13][CH:14]([Cl:17])[CH:15]=O>C(O)(=O)CC>[S:1]([NH:11][N:12]=[CH:15][CH:14]([Cl:17])[Cl:13])([C:4]1[CH:5]=[CH:6][C:7]([CH3:8])=[CH:9][CH:10]=1)(=[O:2])=[O:3]참가 물질
4
실험 절차
Tosylhydrazine (234 g, 1.26 mol) was suspended in propionic acid (2 L) and dichloroacetaldehyde (142 g, 1.26 mol) was added at 15-20° C. The mixture was stirred at room temperature for 2 hours and under ice-cooling for 3 hours. The precipitated crystals were collected by filtration and washed with toluene. The crystals were dried under reduced pressure to give 2,2-dichloroacetaldehyde tosylhydrazone (247 g, yield 70%).
후처리
- temperaturecooling for 3 hours
- filtrationThe precipitated crystals were collected by filtration
- washwashed with toluene
- customThe crystals were dried under reduced pressure
출처 및 근거
- ORD 기록
- ord-15bbb390251345f0a7952e3d8da65690
- 출처 데이터셋
- uspto-grants-2004_06
- 특허 번호
- US06743924B2
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