1,1-Dimethylethyl [(4r)-4-(5-chloro-2-cyano-4-fluorophenoxy)-4-(1-methyl-1h-imidazol-2-yl)butyl]-carbamate → 2-[[(1r)-4-Amino-1-(1-methyl-1h-imidazol-2-yl)butyl]oxy]-4-chloro-5-fluoro-benzonitrile hydrochloride

HRID 352133노트

반응식

HRID 352133 반응식
[Cl:1][C:2]1[C:3]([F:29])=[CH:4][C:5]([C:27]#[N:28])=[C:6]([CH:26]=1)[O:7][C@@H:8]([C:20]1[N:21]([CH3:25])[CH:22]=[CH:23][N:24]=1)[CH2:9][CH2:10][CH2:11][NH:12]C(=O)OC(C)(C)C>Cl.O1CCOCC1>[ClH:1].[NH2:12][CH2:11][CH2:10][CH2:9][C@@H:8]([O:7][C:6]1[CH:26]=[C:2]([Cl:1])[C:3]([F:29])=[CH:4][C:5]=1[C:27]#[N:28])[C:20]1[N:21]([CH3:25])[CH:22]=[CH:23][N:24]=1

참가 물질

4

반응물 1

HCID 914130451,1-Dimethylethyl [(4r)-4-(5-chloro-2-cyano-4-fluorophenoxy)-4-(1-methyl-1h-imidazol-2-yl)butyl]-carbamate

생성물 1

HCID 698293472-[[(1r)-4-Amino-1-(1-methyl-1h-imidazol-2-yl)butyl]oxy]-4-chloro-5-fluoro-benzonitrile hydrochloride수율 157%

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 312751,4-Dioxane용매

실험 절차

The product of step (c) (0.33 g, 0.78 mmol) was dissolved in 4M hydrochloric acid in dioxan (10 ml) and stirred for 10 minutes. The solvent was removed in vacuo and the solid residue triturated with ethyl acetate. The white solid was filtered off and dried under high vacuum to give the title compound (0.22 g, 70%).

후처리

  1. customThe solvent was removed in vacuo
  2. customthe solid residue triturated with ethyl acetate
  3. filtrationThe white solid was filtered off
  4. customdried under high vacuum

출처 및 근거

ORD 기록
ord-0baef9a194c84897ad0469f4d9577267
출처 데이터셋
uspto-grants-2004_06
특허 번호
US06743939B2

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