[4-(5-Chloro-2-cyanophenoxy)-4-(2-thiazolyl)butyl]carbamic acid 1,1-dimethylethyl ester → 2-[4-Amino-1-(2-thiazolyl)butoxy]-4-chlorobenzonitrile hydrochloride

HRID 352143노트

반응식

HRID 352143 반응식
CC(OC(=O)[NH:7][CH2:8][CH2:9][CH2:10][CH:11]([O:17][C:18]1[CH:23]=[C:22]([Cl:24])[CH:21]=[CH:20][C:19]=1[C:25]#[N:26])[C:12]1[S:13][CH:14]=[CH:15][N:16]=1)(C)C>Cl.O1CCOCC1>[ClH:24].[NH2:7][CH2:8][CH2:9][CH2:10][CH:11]([C:12]1[S:13][CH:14]=[CH:15][N:16]=1)[O:17][C:18]1[CH:23]=[C:22]([Cl:24])[CH:21]=[CH:20][C:19]=1[C:25]#[N:26]

참가 물질

4

반응물 1

HCID 70153671[4-(5-Chloro-2-cyanophenoxy)-4-(2-thiazolyl)butyl]carbamic acid 1,1-dimethylethyl ester

생성물 1

HCID 227151012-[4-Amino-1-(2-thiazolyl)butoxy]-4-chlorobenzonitrile hydrochloride수율 65.2%

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 312751,4-Dioxane용매

실험 절차

The product from step (d) (0.20 g) was dissolved in 4M hydrochloric acid in dioxan (5 ml) and stirred for 3hat room temperature. The solvent was evaporated and the residue triturated with dry diethyl ether to give the title compound as a pale yellow solid (0.055 g). M.p 170-172° C.

후처리

  1. customThe solvent was evaporated
  2. customthe residue triturated with dry diethyl ether

출처 및 근거

ORD 기록
ord-a1d87e90e87f417188e4fd7110ca6653
출처 데이터셋
uspto-grants-2004_06
특허 번호
US06743939B2

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