Tetrahydrofuran → N-Benzyl-L-proline

HRID 352210노트

반응식

HRID 352210 반응식
C([O:3][C:4](=[O:17])[C@@H:5]1[CH2:9][CH2:8][CH2:7][N:6]1[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)C.[OH-].[Na+].O1CCCC1>CO>[CH2:10]([N:6]1[CH2:7][CH2:8][CH2:9][C@H:5]1[C:4]([OH:17])=[O:3])[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

참가 물질

5

반응물 3

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 688177N-Benzyl-L-proline ethyl ester

생성물 1

HCID 728719N-Benzyl-L-proline

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

N-Benzyl-L-proline ethyl ester (1.00 g, 4.3 mmol) was combined with aqueous 2N sodium hydroxide (5.0 mL, 10.0 mmol), tetrahydrofuran (2.0 mL) and MeOH (2.0 mL) and the mixture stirred at rt. until hydrolysis was complete. The mixture was then treated in a manner similar to preparation 104. Concentration of the filtrate netted 0.79 g (90%) of crude acid as a light yellowish solid. MS(ES): (M+1)+ 206.3, 207.3.

후처리

  1. customuntil hydrolysis
  2. additionThe mixture was then treated in a manner similar to preparation 104

출처 및 근거

ORD 기록
ord-ad3adf203f894490af333ea0f9558871
출처 데이터셋
uspto-grants-2004_06
특허 번호
US06743794B2

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