Sodium hydride → HCID 22711892, 화합물
반응식
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11](=[O:13])[CH3:12])=[C:6]([Br:14])[CH:5]=1)(=[O:3])[CH3:2].[H-].[Na+].Br[CH2:18][C:19]([CH3:21])=[CH2:20]>CN(C=O)C>[C:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]([CH2:20][C:19]([CH3:21])=[CH2:18])[C:11](=[O:13])[CH3:12])=[C:6]([Br:14])[CH:5]=1)(=[O:3])[CH3:2]참가 물질
5
실험 절차
N-(4-Acetyl-2-bromophenyl)acetamide (25 g, 0.1 mole) in dry DMF (250 ml) was treated with sodium hydride (60%, 4.5 g, 0.11 mole) at 25° C. under argon with stirring for 1 h. 3-Bromo-2-methylpropene (1.1 ml, 0.11 mole) was added and the mixture stirred for a further 16 h. The mixture was concentrated in vacuo and partitioned between water and Et2O. The organic phase was dried and concentrated in vacuo to give the title compound (32.8 g, 100%).
후처리
- stirringthe mixture stirred for a further 16 h
- concentrationThe mixture was concentrated in vacuo
- custompartitioned between water and Et2O
- customThe organic phase was dried
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-aaf3b0ffe06442118a5675e293067f49
- 출처 데이터셋
- uspto-grants-2004_06
- 특허 번호
- US06747030B1
반응 노트
불러오는 중…