2-chloro-N,N-dimethyl-3-nitro-aniline → 2-Chloro-3-dimethylaminoaniline

HRID 352463노트

반응식

HRID 352463 반응식
[CH3:1][N:2]([CH3:13])[C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([N+:9]([O-])=O)[C:4]=1[Cl:12].[H][H]>CO.[Ni]>[Cl:12][C:4]1[C:3]([N:2]([CH3:13])[CH3:1])=[CH:8][CH:7]=[CH:6][C:5]=1[NH2:9]

참가 물질

5

반응물 2

HCID 227123482-chloro-N,N-dimethyl-3-nitro-anilineHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 227123462-Chloro-3-dimethylaminoaniline수율 49.5%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

30.4 g of N,N-dimethyl-2-chloro-3-nitroaniline is dissolved in about 300 ml of MeOH and hydrogenated at 20° C. and 5bars pressure of hydrogen using Raney nickel as catalyst. The solvent is evaporated down and the product is purified by chromatography (silica gel, eluant: petroleum ether/ethyl acetate (3/1)). 12.8 g of 2-chloro-3-dimethylaminoaniline is obtained as a brown oil.

후처리

  1. customThe solvent is evaporated down
  2. customthe product is purified by chromatography (silica gel, eluant: petroleum ether/ethyl acetate (3/1))

출처 및 근거

ORD 기록
ord-9e61eac457a4473dba32450472e134a0
출처 데이터셋
uspto-grants-2004_06
특허 번호
US06747051B2

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