Acetone → 259807-20-0

HRID 352736노트

반응식

HRID 352736 반응식
[ClH:1].CC(C)=O.C(OC([N:13]1[CH2:18][CH2:17][N:16]([C:19]([C:21]2[CH:26]=[CH:25][C:24]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][N+:28]=3[O-:33])=[CH:23][CH:22]=2)=[O:20])[CH2:15][CH2:14]1)=O)(C)(C)C>ClCCl.C(O)C>[ClH:1].[N:16]1([C:19]([C:21]2[CH:26]=[CH:25][C:24]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][N+:28]=3[O-:33])=[CH:23][CH:22]=2)=[O:20])[CH2:17][CH2:18][NH:13][CH2:14][CH2:15]1

참가 물질

6

반응물 3

HCID 180AcetoneHCID 313Hydrochloric AcidHCID 69700183HCID 69700183, 화합물

생성물 1

HCID 22711429259807-20-0

시약·촉매·용매 2

HCID 702Ethanol용매HCID 6344Dichloromethane용매

실험 절차

In dichloromethane (2.5 ml), 2-[4-[[4-(tert-butoxycarbonyl)piperazin-1-yl]carbonyl]phenyl]pyridine N-oxide was dissolved. To the resulting solution, a saturated solution of hydrochloride in ethanol (2.5 ml) was added, followed by stirring at room temperature for 1 hour. After the solvent was distilled off under reduced pressure, water was added to the residue, whereby an aqueous solution was obtained. Acetone was added to the aqueous solution until the solution became turbid. The precipitate was collected by filtration and washed with acetone, whereby the title compound (274 mg, 81%) was obtained.

후처리

  1. distillationAfter the solvent was distilled off under reduced pressure, water
  2. additionwas added to the residue, whereby an aqueous solution
  3. customwas obtained
  4. filtrationThe precipitate was collected by filtration
  5. washwashed with acetone, whereby the title compound (274 mg, 81%)
  6. customwas obtained

출처 및 근거

ORD 기록
ord-53c7e3ae9c8842b384435d70f0881e39
출처 데이터셋
uspto-grants-2004_06
특허 번호
US06747023B1

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